Comparing Efficacy of Propranolol Plus Flunarizine Combination and Valproate Monotherapy in Migraine Prophylaxis in Rural Bengal -A Randomized Control Trial

Abstract

Migraine is second most common cause of headache which is responsible for reduction in the quality of life affects near about 15% of women and 6% of men over a period of 1 year. Affect boys and girls in similar fashion in prepubescent age group, but girls are affected more than boys after that with a rise of incident in fourth decade of life. Propranolol plus Flunarizine combination and sodium valproate are the two widely accepted therapy of migraine prevention. Head to head studies are few with these drugs and we have taken MIDAS Score with reduction of frequency and duration of migraine headache as primary and European quality of life index with EQ-VAS score for quality of life assessment, all these parameters are not included in any other one study. A randomized control trial was done at Bankura Sammilani Medical College with population from rural Bengal, data was taken and detail and appropriate statistical analysis was done with appropriate software. Both the drugs were found very much effective for migraine prophyalxis and improving quality of life. In case of EQ -5D-5L valproate was found to be more effective in improving few parameter.