Risk factors, comorbidities, and social factors associated with alzheimer disease - An observational study from eastern India

Abstract

Alzheimer Disease (AD) is the most common type of dementia worldwide and is a progressive neurodegenerative disorder that results in diminished quality of life and caregiver stress. Although it is not possible to completely prevent the disease with current therapy, several associated comorbidities as well as social and risk factors can be addressed and managed if required. Our study attempts to clarify and delineate the comparative occurrence of these factors in patients presenting with AD and those presenting for other neurologic problems. The results show that diabetes, hyperlipidemia, cerebrovascular disease, and depression are strongly associated with dementia, suggesting etiologic factors and opportunities for timely intervention. Hypertension, dietary factors, occupational factors and marital status did not show a significant correlation. Limitations of the study include the overall elderly population with commonly occurring comorbidities and confounding factors. This study underlines the importance of treating modifiable risk factors with the hope of slowing down or preventing the development of dementia.