A Comparative Study of Fraxinus Excelsior Plus Vitamin-E with Vitamin-E Alone on Liver Function in Non-Alcoholic Fatty Liver Disease (NAFLD) Patients

Abstract

Aims and Objectives: To find the effect of fraxinus excelsior plus vitamin-E with vitamin-E alone on liver function in non-alcoholic fatty liver
disease (NAFLD) patients. Material and Methods: This was a hospital based observational study. The study was conducted on 270 patients,
diagnosed with NAFLD by Ultra sonography (USG) with baseline deranged LFT and lipid profile then were divided in two groups of patients.
Each group consist of 135 patients, group 1 subjects received Vitamin E alone and group 2 subjects received Vitamin E plus Fraxinus Excelsior.
LFT, lipid profile and steatohepatitis grade were investigated in four visits (day1st, day 30 th day, 60th and day90th). Results: In this study baseline
LFT and lipid profile of the patients were deranged in both groups but statistically no significant difference in baseline LFT and lipid profile
between both groups. During 2nd (day 30th), 3rd (day60th) and 4th (day90th) visits mean AST, ALT, ALP, TC, LDL were improved in both groups
including steatohepatitis grade, but more improvement was occurred in group 2 who received combination of Vitamin E + Frexinus excelsior.
There was no statistically significant difference in the mean value of LFT and lipid profile between both group at 30th day but statistical
significance found between both group at 60th day and at 90th day. Steatohepatitis grades were improved in both groups. At 30day, grade 2 was
seen maximum in both groups i.e. 70 (51.9%) and 62 (45.9%) in group 1 and group 2 respectively followed by grade 3. At 60th day steatohepatitis
grade was improved in both groups, grade 2 was seen maximum in both groups i.e. 58 (43%) and 52 (38.4%) in group 1 and group 2 respectively
followed by one. And 90th day steatohepatitis grade was improved in both groups grade 2 was seen maximum in groups 1 i.e. 63 (46.7%)
followed by grade 1 i.e. 40 (29.6%) and in group 2, grade 1 was seen maximum i.e.54 (40%) followed by no grade in 45(33.3%). Conclusion: In
this study, it was observed that consumption of fraxinus excelsior and vitamin E is associated with statistically significant improvement in LFT,
lipid profile and steatohepatitis grade as com- pared to consumption of vitamin E alone.