Comparison of Homocysteine (Hcy) levels and its association with pregnancy induced hypertension

Abstract

Aim: To study the Homocysteine (Hcy) levels in pregnancy induced hypertension. Materials and Methods: A Case control study was conducted in the Department of Obstetrics and Gynaecology, Darbhanga Medical College and Hospital, Laheriasarai, Darbhanga, Bihar, India from 1 year. Total 200 pregnant female subjects in the age group of 16-50 yrs were selected. Out of them 100 were normotensive pregnant women (NPW) in their third trimester and were chosen as control Group 1 and 100 pregnancy induced hypertensive (PIH) patients in their third trimester were chosen as study Group 2. Results: The mean and standard deviation of Homocysteine, uric acid and magnesium levels of NPW and PIH groups. The Hcy level was significantly increased with a mean and standard deviation (SD) value of 20.14±5.87 µmol/l (p- value=0.001) and the uric acid level was also increased with a mean and SD of 6.05±0.67mg/dl (p-value= 0.003) in the PIH. The Hcy level was 9.07 ± 2.24 µmol/land the Uric acid level was 3.41 ± 0.84mg/dl in NPW group. The magnesium level was lower in the PIH compared to NPW (p - value=0.001).

Conclusion: The Hcy and uric acid levels were increased and Magnesium level was decreased in PIH women than the NPW. So these parameters should be part of the evaluation of the pregnant women presenting with hypertension. Thereby, we can reduce the maternal and fetal mortality rate.

Keywords: Homocysteine, Hyperhomocysteinemia, Uric acid, Magnesium and Pregnancy Induced Hypertension (PIH).