An observational study of platelet parameters among patients of diabetes mellitus type 2 at Tertiary Care Centre, Udaipur

Abstract

Introduction: Diabetes Mellitus is a chronic metabolic syndrome principally characterized by persistent hyperglycemia. Fasting blood glucose, postprandial blood glucose, and hemoglobin A1c (HbA1c) are widely used to monitor glycometabolic control in patients with DM. DM is considered as a “prothrombotic state”, Larger platelets that contain denser granules are metabolically and enzymatically more active than smaller ones and have higher thrombotic potential. This study was planned to compare platelet parameters in type 2 diabetic patients and healthy controls. Methodology: This observational study was conducted on patients attending the Medicine and Endocrine OPD of Maharana Bhupal Government hospital during July 2017 to June 2018. Total of 100 subjects with 70 diabetic (type 2) patients attending the diabetic clinic and 30 non diabetics (control group) were selected for study. Result: Mean age of participants were 59.26±12.27 years. Out of 100 participants, 69% had HbA1C more than or equal to 6.5 while 31% had HbA1C less than 6.5. Association of MPV, PDW, HbA1c with complication was found to be statistically significant (p value<0.05) and correlation of HbA1C with MPV and PDW was also statistically significant (p value<0.05). Conclusion: MPV and PDW can be useful as prognostic marker of cardio-vascular complication in diabetics. Both MPV and PDW might be used as a simple and cost – effective laboratory test in the follow up of DM along with HbA1c and thereby help to reduce the morbidity and mortality.