Analysis of lipid profile in various phenotypes of Polycystic ovary syndrome at Tertiary Care facility: An observational study

Abstract

Objective- To assess the sociodemographic and lipid profile (Total cholesterol, Triglycerides and HDL) of various phenotypes of woman with PCOS. Methodology- This observational study was conducted at Tertiary care facility, Jaipur from July 2020 to December 2021 on cases of PCOS aged between 18-35 years attending Gynaecology OPD clinic. 90 women with PCOS, fulfilling the inclusion and exclusion criteria, were enrolled in the study. They were divided into four subgroups- A, B, C and D phenotype. Demographic characteristics, Anthropometric measurementwere done and lipid profile was noted and analysed using SPSS software. Result- Most of cases 38(42.2%) showed D phenotype, followed by A phenotype in 32(35.6%) cases, C phenotype in 12(13.3%) and B phenotype in 8(8.9%) cases. BMI was higher in phenotype A as compared to phenotype D.Mean levels of cholesterol and Triglycerides were significantly higher and mean HDL level was significantly lower in cases with phenotype B as compared to other phenotypes (p value<0.05). Conclusion- It can be concluded that there are raised levels of triglycerides and decreased levels of HDL in androgenic phenotype of PCOS (A, B & C).Women with PCOS should be counselled regarding life style modification including exercise and weight reduction for prevention of cardiovascular events due to dyslipidaemia.