To determine the association of serum VIT D level and uterine fibroid in premenopausal women

Abstract

Background: Uterine Fibroid are monoclonal, benign tumors originating from the smooth muscle cell of uterus and predominantly located in the pelvis. Main hormones for uterine fibroid are estrogen and progesterone. Fibroids mainly consist of extracellular matrix that contain collagen, fibronectin and proteoglycans. vitamin D deficiency has been proven to be a major risk factor in the development of fibroid. Mean 25(OH)D serum levels are significantly low in uterine fibroid women as compared to healthy women. Aims & objectives: To estimate serum vitamin D level in the premenopausal women under age group of 30 to 45 years diagnosed with uterine fibroid and healthy women of same age, weight, locality and ethnicity and to compare serum vitamin D level among both groups. Materials and methods: An observational case control study done in the dept of Obstetrics & Gynaecology of MGM Medical College & M.Y Hospital, Indore Madhya Pradesh from 1st April 2020 to 31st march 2021 in the women attending outpatient dept, in the age group of 30-45 year. After obtaining informed consent, 3 ml of blood sample was collected from all the participants and vit D level measured in the serum by ELISA. Result: total 200 women (100 cases, 100 control) underwent the study. Most study participants among case and control are of age 30-35 years. None of them had BMI below normal and most of control and cases were overweight. Most common parity among them was 2. 91% of cases had vit D deficiency while 32% of control had vit D deficiency and 68% of control were having normal vit D levels. Conclusion: The present study shows there is positive correlation between vit D level and uterine fibroid (OR=21.48), which is suggestive of some contribution of hypovitaminosis of vit D in etiology of uterine fibroid.