A Comparative Study of α2- Agonists as an Adjuvant to Ropivacaine in Epidural Anesthesia for Infraumblical Surgeries

Authors

  • Usma Jabeen Assistant Professor, Department of Anaesthesiology & Critical Care, GMC Rajouri, Jammu & Kashmir, India
  • Suhail Banday Assistant Professor, Department of Anaesthesiology & Critical Care, GMC Rajouri, Jammu & Kashmir, India
  • Mohammad Adil Senior Resident, Department of Anaesthesiology & Critical Care, GMC Rajouri, Jammu & Kashmir, India

Keywords:

Clonidine, dexmedetomidine, epidural, ropivacaine

Abstract

Background: Alpha-2 agonist are being extensively evaluated as an alternative to neuraxial opoids, as an adjuvants in regional anaesthesia The faster onset of action of local anaesthetics, rapid establishment of both sensory and motor blockade, prolonged duration of analgesia into postoperative period, dose sparing action of local anaesthetics and stable cardiovascular parameters make these agents a very effective adjuvant in regional anaesthesia. The aim of our study is to compare the efficacy of two α2- adrenergic agonists, dexmedetomidine and clonidine when used as an adjuvant to ropivacaine in epidural anesthesia for infraumblical surgeries. Materials & Methods: In our study we included 50 patients, of ASA Grade-I or II, between 20- 65 years of age requiring neuraxial blockade for infraumblical surgeries. All the patients were randomly allocated into two groups of 25 each. Group-C: received 15 ml of 0.75% epidural ropivacaine with clonidine 1μg/kg Group-D: received 15 ml of 0.75% epidural ropivacaine with dexmedetomidine 1μg/kg. Patients were monitored for onset of sensory and motor blockade, time to 2 dermatome regression of sensory level, time to first demand for rescue analgesia, sedation, hemodynamic parameters and adverse effects in perioperative period. Results: The onset of sensory block (Group D-8.55 ± 2.81 min, Group C- 12.99 ± 2.96 min), duration of sensory blockade (Group D- 326 ± 35.15 and Group C- 261 ± 36.15) and sedation were found to be significantly better in the dexmedetomidine group. No significant difference was found in terms of onset of motor blockade and hemodynamic changes. Conclusion: Dexmedetomidine is a better neuraxial adjuvant compared to clonidine for providing early onset of sensory analgesia, adequate sedation and a prolonged post-operative analgesia.

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Published

2021-07-31

How to Cite

Usma Jabeen, Suhail Banday, & Mohammad Adil. (2021). A Comparative Study of α2- Agonists as an Adjuvant to Ropivacaine in Epidural Anesthesia for Infraumblical Surgeries. International Journal of Health and Clinical Research, 4(13), 419–422. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/4940

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