Evaluation of deficiency of Vitamin D and low level of Serum Calcium in Hypothyroid Patients
Keywords:
Hypothyroid, calcium, vitamin DAbstract
Background: Autoimmune thyroid diseases, including HT and GD, are the most common organ-specific autoimmune disorders. Vitamin D plays a significant role in modulation of the immune system, enhancing the innate immune response while exerting an inhibitory action on the adaptive immune system.
Aim of the study: To evaluate deficiency of Vitamin D and low level of serum calcium in hypothyroid patients.
Materials and methods: For the present study, we selected a total of 100 patients for the study enrolled from the inpatient department of General Medicine. A complete medical history was taken from each patient and clinical examination was performed. The subjects were grouped into two groups, Group A with 50 hypothyroid patients and Group B with 50 healthy control subjects. Venous samples was taken from all the patients from the antecubital vein. The quantitative determination of 25 –OH vitamin D was carried out by using UV 2005 spectrophotometer method, A serum level of 0-20 ng/ml was considered as deficient, level 21-29 ng/ml was considered insufficient and > 30ng/ml was considered sufficient. Results: In the present study, a total of 100 patietns were studied. Group A contained 50 healthy patients and Group B contained 50 patients with hypothyroidism. The number of male and female patients in Group B was 26 and 24 respectively. The mean age of Group A patients was 49.69 years and Group B patients was 46.25 years. We observed that Serum 25 (OH) Vitamin D was significantly decreased in patients with hypothyroidism. Similarly, serum calcium was also decreased in hypothyroidism patients. The serum TSH level was significantly higher in hypothyroid patients.
Conclusion: Within the limitations of the present study, it can be concluded that the level of serum calcium and serum vit D was significantly decreased in hypothyroid patients in comparison to healthy patients. The level of TSH was significantly increased in hypothyroid patients.