Study of association of Ischaemic Stroke and serum 25-hydroxyvitamin-D Levels

Abstract

Background and Objectives: The association of low vitamin D and cardiovascular diseases and risk factors has been explored in both animal and human studies. This study was undertaken to examine the association of serum 25-hydroxyvitamin D deficiency with ischemic stroke. Material and Methods: The present study comprised 41 consecutive ischemic stroke patients and 45 age and sex matched controls attending the medicine ward of MRA Medical College, Ambedkarnagar, Uttar Pradesh, India, from December 2016 to October 2018. All ischemic stroke patients underwent stroke subtyping. This study was approved by the Institutional Ethics Committee. Data were entered and analysed using the Microsoft excel.Results: Out of forty one stroke patients, 57.7% were men and mean age was 61.0±10.0 years. 25-hydroxy Vitamin D deficiency was observed in 65% stroke patients and 31% controls (P=0.0026). As NIHSS score increases, mean vitamin D levels decreases. Trend shows that negative association between levels of vitamin D severity of stroke. Statistically significant association was found in type of Infract and vitamin D deficiency status.Conclusion: This study found that 25-hydroxyvitamin D deficiency had association with ischemic stroke. Severity of ischemic stroke is inversely related to 25-hydroxyvitamin D levels. Vitamin D deficiency is associated with increased risk of having large stroke as compared to lacunar stroke.