Evaluation of Controlled Hypotensive Anesthesia in spine surgeries by Comparative Administration of Dexmedetomidine and Nitroglycerine

Abstract

Controlled hypotension or induced hypotension is a technique to reduce the blood loss and the necessity of blood transfusion during surgery by improving the visibility of the surgical site and decreasing the arterial blood pressure until hypotension is reached. Hence based on above findings the present study was planned for Evaluation of Controlled Hypotensive Anesthesia in spine surgeries by Comparative Administration of Dexmedetomidine and Nitroglycerine.The present study was planned in Department of Anaesthesia, Vardhman Institute of Medical Science Pawapuri. Nalanda, Bihar. The study was conducted from November 2015 to December 2016. In the present study total 40 patients were selected undergoing the spine surgeries were evaluated. The cases were divided in two study groups as Group D and Group N. The study drug dexmeditomidine was given to group D in the dose of 1 micro gram/kg body weight in a 600 seconds infusion before induction diluted to 10 ml with normal saline followed by maintenance dose at infusion rate of 0.2 - 0.7 microgm/kg. The group N received 10 ml plain normal saline over 600 seconds before induction The data generated from the present study concludes that Controlled hypotension using dexmeditomidine as bolus dose 1 microgram per kg intravenous over 10 minutes prior to induction followed by continuous intravenous infusion at 0.2 - 0.7 microgram per kg per hour, provided more stable hemodynamics and better surgical field quality compared to nitroglycerine intraoperative infusion at 0.5 to 10 microgram/kg/min.