A Compare Study of Effectiveness of oral Bisphosphonates and Vitamin D in Osteoporosis; Gandhi medical college & Hospital, Secunderabad

Abstract

Background: Osteoporosis is a common skeletal disease characterized by a reduction in bone strength and an increased risk of fractures. Treatments for osteoporosis have been shown to increase bone strength and reduce fracture risk. The drugs most commonly used to treat osteoporosis are bisphosphonates and Calcium & Vitamin D supplements. Clinical challenges in using bisphosphonates, Calcium & Vitamin D supplements to treat osteoporosis.Methods: Oral Bisphosphonates, Calcium & Vitamin D supplements to treat osteoporosis include an appropriate selection of patients for initiating therapy. Comparisons between two drugs were done by using paired and unpaired T-test, calculations between before treatment & after treatment. The patient's bone density has been increased following T-score values obtained from DXA (quantitative ultrasound). Results: 120 patients were included. The majority of the adult were aged 38-59 years. Of the 120 students, 69 (57.50%) were males and 51 (42.50%) were females. The proportion of males and females was 1.35:1. In a study amongst 120 Patients, 50 % of Patients are given Ibandronic acid & the other 50 % of Patients s given calcium& Vitamin D. 60 Patients were assessed osteoporotic after DXA-I was treated with Ibandronic acid. After the treatment T-Score was -2.3. 60 Patients were assessed osteoporotic after DXA-II was treated with calcium & Vitamin D. After the treatment T-Score was -2.5. Ibandronic acid shows more effectiveness than calcium & Vitamin D in increasing the BMD in osteoporotic patients. Conclusions: The study summarizes that Patients who are exposed to ibandronic acids show greater results (BMD) rather than subjects who are exposed to calcium & Vitamin D. The study summarizes that oral bisphosphonates show more effectiveness on BMD than calcium supplements for osteoporosis.