Risk Factor Analysis of Vitamin D Insufficiency in End-Stage Renal Disease in CKD Patients: An Institutional Based Study

Abstract

Background: The number of end stage renal disease (ESRD) patients on renal replacement therapy (RRT) is increasing all over the world, diabetes mellitus (DM) being the leading cause. Hence; the present study was conducted for assessing the risk factor of vitamin d insufficiency in end-stage renal disease in CKD patients. Materials & Methods: A total of 100 CKD patients were enrolled. Complete demographic and clinical details of all the patients were obtained. Blood pressure was measured with a brachial sphygmomanometer. Prescribed doses of oral vitamin D analogue (alfacalcidol) were recorded. Alfacalcidol was administered when serum calcium was less than 8.5 mg/dL and serum intact parathyroid hormone (PTH) higher than 150 pg/mL after titration with CaCO3. Blood samples were obtained, and serum profile was evaluated. All the results were recorded, and Microsoft excel sheet. Results: Mean BMI was significantly higher among the patients with 25(OH)D < 15 ng/mL in comparison to the patients with 25(OH)D > 15 ng/mL. Mean calcium levels was significantly lower among the patients with 25(OH)D < 15 ng/mL in comparison to the patients with 25(OH)D > 15 ng/mL. Mean haemoglobin levels was significantly lower among the patients with 25(OH)D < 15 ng/mL in comparison to the patients with 25(OH)D > 15 ng/mL. Mean triglycerides levels was significantly higher among the patients with 25(OH)D < 15 ng/mL in comparison to the patients with 25(OH)D > 15 ng/mL. Conclusion: From the above results, the authors concluded that vitamin D deficiency affects a significant proportion of CKD patients with end stage renal disease. BMI, Calcium levels, haemoglobin and triglycerides were significant risk factors associated with vitamin d insufficiency in end-stage renal disease in CKD patients.