Comparative evaluation of Ketorolac alone and Ketorolac with Olopatadine eye drop for allergic conjunctivitis

Abstract

Background: Seasonal allergic conjunctivitis is the most common allergic disorder of eyes. Aim: to evaluate the efficacy of 0.4% Ketorolac eye drop alone and 0.4% ketorolac with 0.1% Olopatadine eye drop in seasonal allergic conjunctivitis.Material and Method: The study was prospective, double blind parallel group comparative. Two hundred cases enrolled in the study. All the subjects were randomly divided in two groups, 100 in each. Group 1 patients received 0.4% ketorolac eye drop in both eyes 2 times a day and group 2 patients received combination of 0.1% olopatadine and 0.4% ketorolac in both eyes 2 times a day. Observations were collected at baseline and on day 3,7,15 and analyzed statistically regarding improvement in sign and symptoms. Result: In group 1, 50- 60% patients had no sign and symptoms on day 15 whereas in group 2 more than 95% patients showed improvement in clinical picture. p value was significant (p<0.0001) at day 15 in all sign and symptoms and on day 3 in itching and on day 7 in watering. Overall group 2 patients had better and earlier response regarding symptoms of itching at day 3.  Conclusion: The combination of 0.1% olopatadine and 0.4% ketorolac was more effective than 0.4% ketorolac alone in seasonal allergic conjunctivitis patients.