Utility of urinary uric acid and creatinine ratio as a marker of neonatal asphyxia: a comparative assessment

Abstract

Aim: to assess the utility of urine uric acid creatinine ratio (UA/Cr) as an additional marker of neonatal depression and birth asphyxia and it’s utility as a potential prognostic indicator for the immediate outcome. Material and methods: This prospective observational study was carried out in the Department of Pediatrics, Kalawati Saran Children Hospital, New Delhi, India for 1 year in this study that included 200 newborns born. Newborns with encephalopathy were considered to have an unfavourable outcome. The urine UA/Cr was estimated in both groups.

Results: The mean differences of urine UA/Cr were statistically significant in birth asphyxia (3.26±1.37), and controls (2.02± 0.71). Conclusion: The urine UA/Cr is a useful diagnostic and prognostic biomarker in newborns with birth asphyxia.

Keywords: UA/Cr, Biomarker, Birth asphyxia