Prevalence of sickle cell disorder in patients visited to tertiary care hospital

Abstract

Background: Sickle cell disease (SCD) is prevalent in many countries of the world. In India, it is more common in central and southern parts of the country. Because of this fact, this study was initiated to study the prevalence of sickle cell disease.Methods: Diagnosis of SCD was done by sickling slide tests, solubility test and haemoglobinopathies were determined by cellulose acetate membrane tests.Results: 2,386 patients were screened by sickling slide test, and 109 SCD cases (4.55%) were detected. The same cases were also positively identified by solubility test. Electrophoretograms showed 4 (3.66%) of the study subjects were having SS type of Hb pattern while 105 (96.33%) were AS of Hb pattern.Conclusion: Sickle Cell Disease is prevalent in this area which is around 4.55%. There should be evaluation of relatives for the purpose of early diagnosis.