Role of D dimer, Prothrombin Time, Activated partial thromboplastin time in predicting the severity and prognosis in patients with COVID-19: A Tertiary Care Centre Study In Gwalior
Keywords:D dimer, Covid -19, Coagulation
Introduction:COVID-19 has emerged as a pandemic. There is an overactivated immune response causing cytokine storm. Deranged haemostasis has been observed in patients with COVID-19 pointing more towards prothrombotic state. Clinical laboratory coagulation indexes, like D-dimer (DD), prothrombin time (PT), activated partial thromboplastin time (aPTT) can reflect the clotting state of the patient. Significant correlation between coagulating factors and disease outcome have been quoted by many studies. Aim:The aim of the study is to investigate role of the dynamic changes of coagulation parameters in predicting prognosis among the COVID-19 patients.Material and Methods:In this study, a total of 630 patients with confirmed COVID-19 were included. D-dimer, PT and aPTT values were obtained at the time of admission. Follow up second and third D-dimer values were also obtained wherever feasible. Comparison was made using each parameter between the mortality and non-mortality group.Results:There was a significant difference of D-Dimer (Baseline) between mortality and non-mortality group (W = 23581.000, p = <0.001), with the median D-Dimer (Baseline) being highest in the mortality present group. Similar result was seen with D-Dimer (1st Repeat) (W = 275.500, p = 0.049). Moreover, participants with baseline D-dimer > 2μg/ml had the larger largest proportion of mortality.
Conclusion:It was concluded that raised D – dimer among the covid-19 patients is associated with high risk of morbidity and mortality.
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Copyright (c) 2021 Reena Jain, Reema Bhushan, Prakriti Gupta, KS Mangal
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