Role Of Interleukin 6, Ferritin, Troponin I, Procalcitonin and D Dimer in COVID 19: A Tertiary Care Centre Study In Central India
Keywords:COVID 19, IL 6, Troponin I, D Dimer
Background: COVID 19, a febrile respiratory illness caused by a novel coronavirus, severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), emerged in Wuhan China in December 2019. Cytokine storm and hyper inflammation consisting of elevated serum C-reactive protein (CRP), procalcitonin (PCT), D-dimer, and hyperferritinemia have been reported in COVID 19. Troponin I elevation is found in many studies. This is an attempt to study the role Of Interleukin 6, Ferritin, Troponin I, Procalcitonin and D Dimer in COVID 19 disease in Indian population. Material and methods: This is a retrospective observational study on 933 patients admitted for COVID 19. Data on demographic characteristics and laboratory tests were collected from electronic and paper medical records. Patients were categorized into mild and severe groups (MDG and SDG). Results: Serum levels of IL 6, ferritin, procalcitonin, troponin I and d dimer were compared in SDG and MDG, with statistically significant rise in SDG found in IL 6, Troponin I and D dimer, p = 0.00001, 0.012 and 0.001 respectively. Mortality rate was found to be 11.36 %. Inflammatory markers and D dimer showed significant rise in deceased patients as compared to survivors. Conclusion: Data on inflammatory markers is limited in patients with COVID-19 in India. We observed significantly raised IL 6, troponin I and PCT in severe COVID 19 and results showed their effectiveness of IL 6, PCT, Ferritin and D dimer in assessing disease severity and predicting mortality in patients with COVID-19.
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Copyright (c) 2021 Reema Bhushan, Prakriti Gupta, Reena Jain
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