A Comparative study of Ramosetron Versus Ondansetron for Prevention of Postoperative Nausea and Vomiting in patients undergoing laproscopic surgeries under general anaesthesia

Authors

  • Rekha Kumari Senior Resident, Department of Anesthesia and Critical Care, Patna Medical College and Hospital, Patna, Bihar, India
  • Shafqat Arfin Associate Professor, Department of Anesthesia and Critical Care, Patna Medical College and Hospital, Patna, Bihar, India
  • Madiha Shadab Senior Resident, Department of Anesthesia and Critical Care, Patna Medical College and Hospital, Patna, Bihar, India

Keywords:

Postoperative nausea and vomiting (PONV), Ramosetron, Ondansetron.

Abstract

Background: Nausea and vomiting are distressing symptoms after laparoscopic surgeries. Number of drugs is used but none is devoid of side effects. Introduction of 5-HT3 receptors antagonists heralded the major advance in the treatment of postoperative nausea and vomiting. Hence search for ideal new 5-HT3 receptors antagonists goes on. Aim: The aim of the present study was to compare the efficacy of intravenous ramosetron and ondansetron for prevention of postoperative nausea and vomiting in patients undergoing elective laparoscopic surgeries under general anaesthesia. Subjects and Methods: 144 patients of ASA physical status I and II, posted for elective laparoscopic surgeries under general anaesthesia were included in this prospective randomized study. Patients were randomly allocated into two groups to receive either injection Ramosetron 0.3 mg or injection Ondansetron 4 mg intravenously. Incidence of nausea, vomiting or both, need of rescue antiemetic and complete response were recorded for 24 hrs. Data was analyzed statistically. Results: Overall incidence of PONV was observed in 15.27% patients in group R and 36.11% in group O. Rescue antiemetic was used in 5.55% patients in group R compared to 22.22% in group O. Complete response was found in 84.74% patients of group R and 63.88% of group O. Conclusion: Intravenous Ramosetron with dose of 0.3 mg appears to be a promising drug for prevention of postoperative nausea and vomiting in laparoscopic surgery under general anaesthesia.

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Published

2021-10-01

How to Cite

Rekha Kumari, Shafqat Arfin, & Madiha Shadab. (2021). A Comparative study of Ramosetron Versus Ondansetron for Prevention of Postoperative Nausea and Vomiting in patients undergoing laproscopic surgeries under general anaesthesia. International Journal of Health and Clinical Research, 4(17), 58–61. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/2764

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