A Study on Evaluation of Predictive Value of Microalbuminuria as a Screening Tool for Pre-eclampsia Among Patients Attending A Tertiary Care Centre Of Bihar
Introduction: Proteinuria is a defining dysfunction of Pre-eclampsia (PE) and repeated urinalysis to screen for the condition is part of the standard antenatal care. It has been proposed to be an indicator of both the severity of disease and the prediction of its outcome. Studies have shown that the presence of microalbuminuria earlier in pregnancy is associated with an increased risk of development of PE and severe adverse maternal and fetal outcome in PE. The aim of this study was to assess the role of microalbuminuria as a diagnostic marker in PE. Methodology: The current study was conducted by the Dept of Obstetrics and Gynecology, Nalanda Medical College & Hospital, Patna, Bihar, India during August 2021 to February 2022. Ethical clearance was obtained from the ethical committee of the institution. Informed consent was obtained from all the subjects. The study incorporated 25 normotensive pregnant women as controls and 25 pregnant women between 20 and 35 years of age were selected at 24 ± 4 weeks of gestation and had PIH diagnosed by the accepted criteria of the Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy with a blood pressure of >140/90 mm Hg and proteinuria (>300 mg/24-h). Results: The mean age (with SD) of patients from normotensive and PE group was 26.4 ± 3.4 years and 27.3 ± 4.1 years, respectively. The mean period of gestation was 32.2 ± 4.2 weeks and 29.7 ± 5.1 weeks respectively for both the study cohorts. The sensitivity and specificity of the various renal function parameters in PE was calculated. The sensitivity of micro albumin was 100% and the specificity was 78.2%, both being the highest among all renal function markers except creatinine, which had a higher specificity. Urea had a sensitivity of 80% and specificity of 65.7% while creatinine had a sensitivity of 72% but had a specificity of 81.2%. Conclusion: The current created evidence that microalbuminuria is a good diagnostic marker for PIH, although it may not be preferred for grading its severity.
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Copyright (c) 2022 Ravi Kumar Raman, Rekha Kumari, Rajan Kumar
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