To compare the clinical parameters and lipid profile in chronic kidney disease patients with and without hemodialysis

Abstract

Background & Method: The present study is comparative observational study; entitled - To compare the clinical parameters and lipid profile in chronic kidney disease patients with and without hemodialysis has been conducted in the Department of Medicine in Jaya Arogya Hospital, Gwalior on an inpatient basis. All the selected patients were subjected to relevant investigations like CBC, Blood urea, Serum creatinine, total protein, serum albumin, serum electrolytes, serum bilirubin, SGPT, Blood Sugar, lipid profile, Urine Routine and Microscopy test and USG abdomen. Result: Among the studied 100 patients, maximum cases belonged to the age group 41-50 years (n=29). Out of studied 100 patients, 67 were male and 33 were female. In our study, most common clinical sign was pallor (found in 76% patients), and most common clinical symptom was oliguria (70%), followed by swelling of legs and edema (69% each), while facial puffiness and breathlessness was found in 48% and 45% patients respectively. On comparing the value of triglyceride and VLDL the value were found to be higher in Chronic kidney disease (CKD) patients with hemodialysis than CKD patients without hemodialysis which was statistically significant with p value <0.00001 (each).The value of HDL was lower CKD patients with hemodialysis than CKD patients without hemodialysis which was statistically significant with p value of 0.00672.Total cholesterol and LDL were also marginally raised in CKD patients with hemodialysis than CKD patients without hemodialysis. But this difference was not statistically significant with p value of 0.1723 and .09938 respectively. Conclusion: Hemodialysis effectively reduced the accumulation nitrogenous waste product but fails to correct uremic dyslipidemia completely rather it may alter the pattern of dyslipidemia as seen in our study. The value of triglyceride (TG) and VLDL value were higher while the value of HDL was lower in CKD patients with hemodialysis than CKD patients without hemodialysis which were statistically significant (p value <0.05).Total cholesterol and LDL were also marginally raised in patients of CKD with hemodialysis than CKD patients without hemodialysis, but this was not found to be statistically significant (p value >0.05).Dyslipidemia, being modifiable risk factor, becomes an important component in the management of CKD patients. A strict monitoring of lipid profile can reduce the morbidity and mortality in these patients and will also improve the quality of life of patients of ESRD and use the lipid lowering agents in patients of dyslipidemia as per guidelines for improving cardiovascular outcome.