Formulation and evaluation of sustained release floating microspheres of ketorolac using chitosan as a natural polymer

Abstract

Sustained release medication conveyance Systems is a way to deal with broaden the gastric duration of medication in stomach. This technique is intended for site-explicit oral medications with low mass thickness than gastric liquid so on light the measurement structures in stomach to expand the span of the medication and consequently improve the bioavailability of medication. As a response to the issue, gastroretentive medication conveyance frameworks (SRDDS), which highlight an improved gastric length (GRT), were created.
The in vitro data indicated that pure drug showed 100% release within 2 hr. The drug release from the microspheres prepared in formulation F6 achieved 92.40±0.2% in 24 hr. per model fitting methods the very best parametric statistic (R2) value was 0.978 through Higuchi order model. Hence from all aspects; we concluded that the discharge of drug Ketorolac will be controlled by proper designing of the formulation and selection of an acceptable method of preparation.